In general, BUN levels rise as people get older. A result of more than 50 mg/dL shows the presence of an underlying medical condition.īUN levels vary by gender and age, as well as during pregnancy. The typical range for blood urea nitrogen levels is 7 to 22 mg/dL. As a result, maintaining normal blood urea nitrogen levels is critical. When the liver or kidneys are damaged, the BUN levels rise. Under normal circumstances, the kidneys filter urea nitrogen, which is then excreted in the urine. The waste product of breakdown of proteins in the liver is urea nitrogen. It determines the amount of urea nitrogen in the blood. Each laboratory which analyzes these values could have somewhat different ranges, but it’s not something We want you to worry about right now.Ī blood urea nitrogen (BUN) test is used to detect how well your kidneys are working. The ammonia is subsequently changed to urea in the liver, which then travels through the bloodstream to the kidneys, in which it is expelled as a waste product in urine.Īs a result, blood tests can be used to assess the BUN level, or the blood urea nitrogen, in our body, which is a key sign of liver and, more importantly, kidney health.īUN levels in the blood is varies from 8 to 18 milligrammes per deciliter. BUN (Blood Urea Nitrogen)Ī chemical called ammonia is produced if proteins are digested by our body. BUN levels can be raised by conditions like heart failure, shock, a high-protein diet, and gastrointestinal bleeding. As the glomerular filtration rate (GFR) declines owing to sick or injured kidneys, BUN builds up in the blood. The liver produces urea, which is then transported by that of the blood to kidneys for elimination. This is one of the oldest heart failure prognostic indicators. Where 60 represents MW of urea and 14*2 MW of urea nitrogen.The serum consequence of protein metabolism is blood urea nitrogen (BUN). Elsewhere, the concentration of urea is reported in SI units as mmol/L.ī U N m g / d L United States, Mexico, Italy, Austria, and Germany). OTC deficiency is also accompanied by hyperammonemia and high orotic acid levels.īUN is usually reported in mg/dL in some countries (e.g. Reference ranges for blood tests, comparing urea (yellow at right) to other blood constituentsĪnother rare cause of a decreased BUN is ornithine transcarbamylase deficiency, which is a genetic disorder inherited in an X-linked recessive pattern. The main causes of a decrease in BUN are malnutrition (low-protein diet), severe liver disease, anabolic state, and syndrome of inappropriate antidiuretic hormone. Hypothyroidism can cause both decreased GFR and hypovolemia, but BUN-to-creatinine ratio has been found to be lowered in hypothyroidism and raised in hyperthyroidism. The main causes of an increase in BUN are: high-protein diet, decrease in glomerular filtration rate (GFR) (suggestive of kidney failure), decrease in blood volume ( hypovolemia), congestive heart failure, gastrointestinal hemorrhage, fever, rapid cell destruction from infections, athletic activity, excessive muscle breakdown, and increased catabolism. The normal range is 2.1–7.1 mmol/ L or 6–20 mg/ dL. Interpretation īUN is an indication of kidney health. It is not considered as reliable as creatinine or BUN-to-creatinine ratio blood studies. The test is used to detect kidney problems. Individual laboratories may have different reference ranges, as they may use different assays. Normal human adult blood should contain 7 to 18 mg/dL (0.388 to 1 mmol/L) of urea nitrogen. The liver produces urea in the urea cycle as a waste product of the digestion of protein. 6299-2, 59570-2, 12961-9, 12963-5, 12962-7īlood urea nitrogen ( BUN) is a medical test that measures the amount of urea nitrogen found in blood.
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